Nerolidol is a sesquiterpene alcohol found in many aromatic plants including jasmine, tea tree, lemongrass, and ginger. It exists in two isomeric forms: trans-nerolidol and cis-nerolidol. This terpene is of particular interest in pharmacology for its remarkable ability to enhance the penetration of other compounds through biological membranes, including skin.
Research has demonstrated nerolidol's potential as a transdermal penetration enhancer, making it valuable for topical drug delivery formulations. Studies published in the International Journal of Pharmaceutics showed that nerolidol significantly increased the skin absorption of various therapeutic compounds. Beyond its enhancing properties, nerolidol exhibits sedative, antifungal, and antiparasitic activities, with research suggesting potential applications against Leishmania parasites and various fungal infections.
In terpene formulation, nerolidol provides a subtle, complex woody-floral note that adds depth to blends. Its penetration-enhancing properties make it strategically important in topical cannabis products where it can improve the delivery of cannabinoids and other terpenes through the skin.
